ea0014p28 | (1) | ECE2007
Kudo Takanori
, Ogawa Yoshiji
, Suga Sechiko
, Tomotsune Ken
, Hasegawa Noriyuki
, Suda Toshihiro
, Wakui Makoto
A sustained, high circulating level of free fatty acids (FFAs) is an important risk factor for the development of insulin resistance, islet beta-cell dysfunction, and pathogenesis of type 2 diabetes. Here, we report a novel mechanism of chronic exposure of oleic acid (OA)-induced rat insulin release impairment. Following a 4-day exposure to 0.1 mM OA, there was no significant difference in basal insulin release when comparing OA-treated and untreated islets in the presence of ...